本草光语·大健康研究实验室徽章本草光语·大健康研究实验室HERBAL PHOTONICS & HEALTH RESEARCH LABORATORY
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Nature Communications · 2026

Molecular imaging-guided discovery of a potent natural FAPα inhibitor for liver fibrosis therapy

Wenze Zhang, Jiwei Li, Lei Sun, Chaoran Li, Kaiyu Zhang, Zhiying He, Guangyi Yang, Boyang Yu, Xianchuang Zheng, Haijun Xu, Jiangwei Tian et al.

Molecular imaging-guided discovery of a potent natural FAPα inhibitor for liver fibrosis therapy代表性科研图片代表性科研图片 · 图片来源于课题组提供的论文及项目成果资料

RESEARCH HIGHLIGHT

研究亮点

构建FAPα响应型荧光/光声双模探针Cs-FAP，从95种药用植物中筛得天然FAPα抑制剂苏木查尔酮，并在三类肝纤维化模型中验证其治疗潜力。

完整引文

Wenze Zhang, Jiwei Li, Lei Sun et al. Molecular imaging-guided discovery of a potent natural FAPα inhibitor for liver fibrosis therapy. Nature Communications (2026).

光学探针生物成像天然活性物质机制研究
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